Congenital Vascular Defect Associated with Platelet Abnormality and Antihemophilic Factor Deficiency
نویسندگان
چکیده
منابع مشابه
Congenital vascular defect associated with platelet abnormality and antihemophilic factor deficiency.
With the assistance of Mrs. Ruth T. Davidson and Mrs. Mary Jane Ussery T HE CONGENITAL hemorrhagic diseases characterized by prolonged bleeding time are poorly classified and incompletely understood. The bleeding tendency in these diseases is usually attributed to ( a ) a “defect of the capillary wall,” or ( b ) a “qualitative defect of platelets.” Under the first heading are included those ind...
متن کاملA fatal congenital defect associated with a unique chromosome abnormality.
Case Report Maternal History. The father and mother were both aged 39 and were first cousins. There was no maternal history of radiation. This was the seventh pregnancy. She had had a previous stillbirth, but all babies with the exception of the present had been born at home. The 5 children, aged from 3 to i6 years, were alive and well. A normal live child was born to the parents I9 months afte...
متن کاملAmaurosis fugax associated with congenital vascular defect
A 68-year-old female with no significant past medical history presented with loss of vision in the lower half of her left eye that lasted <5 minutes. No abnormalities were found on ocular or physical exam. Computed tomography angiography and carotid ultrasound were performed, which confirmed the diagnosis as amaurosis fugax with two abnormalities leading to the transient retinal vessel occlusio...
متن کاملDiathesis Associated with a Qualitative Platelet Factor V Deficiency
Studies were performed on a FrenchCanadian family afflicted with a bleeding disorder exhibiting an autosomal dominant inheritance pattern and a severe bleeding diathesis after trauma. Clinical laboratory coagulation tests were unimpressive; the only persistent abnormalities include mild thrombocytopenia and moderately reduced Factor V clotting activities. Some individuals had prolonged Stypven ...
متن کاملAn autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen and an epinephrine aggregation defect.
Multimerin is a massive soluble, multimeric protein found in platelets and endothelial cells. Recent studies identified multimerin as a specific coagulation factor V binding protein, complexed with platelet, but not plasma, factor V. These findings led us to investigate individuals with inherited factor V deficiencies for possible multimerin abnormalities. Platelet proteins were evaluated using...
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ژورنال
عنوان ژورنال: Blood
سال: 1960
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v15.6.807.807